ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Enhancer of polycomb homolog 1

Intramolecular
Cysteine 451 and cysteine 22
Cysteine 441 and cysteine 550
Cysteine 222 and cysteine 225
A redox-regulated disulphide may form within Enhancer of polycomb homolog 1 between cysteines 451 and 22 (402 and 446 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6nfx
Structure name
mbtd1 mbt repeats
Structure deposition date
2018-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2F5
Residue number A
451
Residue number B
22
Peptide name
Enhancer of polycomb homolog 1

Ligandability

Cysteine 451 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 22 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Enhancer of polycomb homolog 1 between cysteines 441 and 550 (510 and 550 respectively in this structure).

Details

Redox score ?
nan
PDB code
6nfx
Structure name
mbtd1 mbt repeats
Structure deposition date
2018-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2F5
Residue number A
441
Residue number B
550
Peptide name
Enhancer of polycomb homolog 1

Ligandability

Cysteine 441 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 550 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 510 has been assigned to correct residue.
Cysteine 550 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Enhancer of polycomb homolog 1 between cysteines 222 and 225.

Details

Redox score ?
nan
PDB code
6nfx
Structure name
mbtd1 mbt repeats
Structure deposition date
2018-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2F5
Residue number A
222
Residue number B
225
Peptide name
Enhancer of polycomb homolog 1

Ligandability

Cysteine 222 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Enhancer of polycomb homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 in protein A could not be asigned to a Uniprot residue.
Cysteine 225 in protein B could not be asigned to a Uniprot residue.
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