Ubiquitin-protein ligase E3A
Intramolecular
Cysteine 26 and cysteine 34
Cysteine 21 and cysteine 26
Cysteine 26 and cysteine 60
Cysteine 26 and cysteine 31
Cysteine 31 and cysteine 34
Cysteine 21 and cysteine 60
Cysteine 21 and cysteine 31
Cysteine 31 and cysteine 60
Cysteine 21 and cysteine 34
Cysteine 34 and cysteine 60
2kr1 A 26 A 34
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 26 and 34.
Details
Redox score ?
90
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
0
Peptide accession
Q9H2G0
Residue number A
26
Residue number B
34
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 26 of Ubiquitin-protein ligase E3A
Cysteine 34 of Ubiquitin-protein ligase E3A
2kr1 A 21 A 26
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 21 and 26.
Details
Redox score ?
84
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
0
Peptide accession
Q9H2G0
Residue number A
21
Residue number B
26
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 21 of Ubiquitin-protein ligase E3A
Cysteine 26 of Ubiquitin-protein ligase E3A
2kr1 A 26 A 60
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 26 and 60.
Details
Redox score ?
83
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
8
Peptide accession
Q9H2G0
Residue number A
26
Residue number B
60
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 26 of Ubiquitin-protein ligase E3A
Cysteine 60 of Ubiquitin-protein ligase E3A
2kr1 A 26 A 31
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 26 and 31.
Details
Redox score ?
83
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
11
Peptide accession
Q9H2G0
Residue number A
26
Residue number B
31
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 26 of Ubiquitin-protein ligase E3A
Cysteine 31 of Ubiquitin-protein ligase E3A
2kr1 A 31 A 34
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 31 and 34.
Details
Redox score ?
80
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
12
Peptide accession
Q9H2G0
Residue number A
31
Residue number B
34
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 31 of Ubiquitin-protein ligase E3A
Cysteine 34 of Ubiquitin-protein ligase E3A
2kr1 A 21 A 60
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 21 and 60.
Details
Redox score ?
80
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
8
Peptide accession
Q9H2G0
Residue number A
21
Residue number B
60
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 21 of Ubiquitin-protein ligase E3A
Cysteine 60 of Ubiquitin-protein ligase E3A
2kr1 A 21 A 31
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 21 and 31.
Details
Redox score ?
80
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
12
Peptide accession
Q9H2G0
Residue number A
21
Residue number B
31
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 21 of Ubiquitin-protein ligase E3A
Cysteine 31 of Ubiquitin-protein ligase E3A
2kr1 A 31 A 60
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 31 and 60.
Details
Redox score ?
75
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
18
Peptide accession
Q9H2G0
Residue number A
31
Residue number B
60
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 31 of Ubiquitin-protein ligase E3A
Cysteine 60 of Ubiquitin-protein ligase E3A
2kr1 A 21 A 34
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 21 and 34.
Details
Redox score ?
74
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
1
Peptide accession
Q9H2G0
Residue number A
21
Residue number B
34
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 21 of Ubiquitin-protein ligase E3A
Cysteine 34 of Ubiquitin-protein ligase E3A
2kr1 A 34 A 60
A redox-regulated disulphide may form within Ubiquitin-protein ligase E3A between cysteines 34 and 60.
Details
Redox score ?
67
PDB code
2kr1
Structure name
solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens
Structure deposition date
2009-11-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
8
Peptide accession
Q9H2G0
Residue number A
34
Residue number B
60
Peptide name
Ubiquitin-protein ligase E3A
Ligandability
Cysteine 34 of Ubiquitin-protein ligase E3A
Cysteine 60 of Ubiquitin-protein ligase E3A
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