STE20-like serine/threonine-protein kinase

Intramolecular

A redox-regulated disulphide may form within STE20-like serine/threonine-protein kinase between cysteines 136 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

8bem

Structure name

ste20-like serine/threonine-protein kinase (slk) in complex with tivozanib

Structure deposition date

2022-10-21

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q9H2G2

Residue number A

136

Residue number B

272

Peptide name

STE20-like serine/threonine-protein kinase

Ligandability

Cysteine 136 of STE20-like serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.