ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Golgin-45

Intermolecular
Cysteine 103 of Golgi reassembly-stacking protein 2 and cysteine 393
Cysteine 103 of Golgi reassembly-stacking protein 2 and cysteine 396
Cysteine 173 of Golgi reassembly-stacking protein 2 and cysteine 392
Intramolecular
Cysteine 393 and cysteine 396
Cysteine 392 and cysteine 393
Cysteine 392 and cysteine 396
A redox-regulated disulphide may form between cysteine 103 of Golgi reassembly-stacking protein 2 and cysteine 393 of Golgin-45.

Details

Redox score ?
71
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
nan
Peptide A name
Golgi reassembly-stacking protein 2
Peptide B name
Golgin-45
Peptide A accession
Q99JX3
Peptide B accession
Q8R2X8
Peptide A residue number
103
Peptide B residue number
393

Ligandability

Cysteine 103 of Golgi reassembly-stacking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 103 of Golgi reassembly-stacking protein 2 and cysteine 396 of Golgin-45.

Details

Redox score ?
69
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
72
Peptide A name
Golgi reassembly-stacking protein 2
Peptide B name
Golgin-45
Peptide A accession
Q99JX3
Peptide B accession
Q8R2X8
Peptide A residue number
103
Peptide B residue number
396

Ligandability

Cysteine 103 of Golgi reassembly-stacking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 173 of Golgi reassembly-stacking protein 2 and cysteine 392 of Golgin-45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
13
% buried
100
Peptide A name
Golgi reassembly-stacking protein 2
Peptide B name
Golgin-45
Peptide A accession
Q99JX3
Peptide B accession
Q8R2X8
Peptide A residue number
173
Peptide B residue number
392

Ligandability

Cysteine 173 of Golgi reassembly-stacking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Golgin-45 between cysteines 393 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
19
% buried
nan
Peptide accession
Q8R2X8
Residue number A
393
Residue number B
396
Peptide name
Golgin-45

Ligandability

Cysteine 393 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Golgin-45 between cysteines 392 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
nan
Peptide accession
Q8R2X8
Residue number A
392
Residue number B
393
Peptide name
Golgin-45

Ligandability

Cysteine 392 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Golgin-45 between cysteines 392 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5h3j
Structure name
crystal structure of grasp domain of grasp55 complexed with the golgin45 c-terminus
Structure deposition date
2016-10-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
13
% buried
86
Peptide accession
Q8R2X8
Residue number A
392
Residue number B
396
Peptide name
Golgin-45

Ligandability

Cysteine 392 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of Golgin-45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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