ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CXXC-type zinc finger protein 4

Intramolecular
Cysteine 142 and cysteine 145
Cysteine 154 and cysteine 157
Cysteine 157 and cysteine 167
Cysteine 139 and cysteine 172
Cysteine 145 and cysteine 172
Cysteine 139 and cysteine 142
Cysteine 142 and cysteine 172
Cysteine 151 and cysteine 154
Cysteine 154 and cysteine 167
Cysteine 139 and cysteine 145
More...
Cysteine 151 and cysteine 167
Cysteine 151 and cysteine 157
A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 142 and 145.

Details

Redox score ?
78
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
142
Residue number B
145
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 142 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 154 and 157.

Details

Redox score ?
77
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
154
Residue number B
157
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 154 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 157 and 167.

Details

Redox score ?
77
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
157
Residue number B
167
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 157 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 139 and 172.

Details

Redox score ?
76
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
139
Residue number B
172
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 139 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 145 and 172.

Details

Redox score ?
76
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
145
Residue number B
172
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 145 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 139 and 142.

Details

Redox score ?
76
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
139
Residue number B
142
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 139 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 142 and 172.

Details

Redox score ?
75
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
142
Residue number B
172
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 142 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 151 and 154.

Details

Redox score ?
75
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
151
Residue number B
154
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 151 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 154 and 167.

Details

Redox score ?
74
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
154
Residue number B
167
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 154 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 139 and 145.

Details

Redox score ?
74
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
139
Residue number B
145
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 139 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 151 and 167.

Details

Redox score ?
73
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
151
Residue number B
167
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 151 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 4 between cysteines 151 and 157.

Details

Redox score ?
72
PDB code
5vc9
Structure name
zinc finger of human cxxc4 in complex with cpg dna
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H2H0
Residue number A
151
Residue number B
157
Peptide name
CXXC-type zinc finger protein 4

Ligandability

Cysteine 151 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of CXXC-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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