ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-dependent DNA/RNA helicase DHX36

Intramolecular
Cysteine 838 and cysteine 911
Cysteine 715 and cysteine 979
Cysteine 715 and cysteine 716
Cysteine 263 and cysteine 312
A redox-regulated disulphide may form within ATP-dependent DNA/RNA helicase DHX36 between cysteines 838 and 911. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5vha
Structure name
dhx36 with an n-terminal truncation
Structure deposition date
2017-04-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
Q05B79
Residue number A
838
Residue number B
911
Peptide name
ATP-dependent DNA/RNA helicase DHX36

Ligandability

Cysteine 838 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 911 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA/RNA helicase DHX36 between cysteines 715 and 979. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5vha
Structure name
dhx36 with an n-terminal truncation
Structure deposition date
2017-04-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
42
Peptide accession
Q05B79
Residue number A
715
Residue number B
979
Peptide name
ATP-dependent DNA/RNA helicase DHX36

Ligandability

Cysteine 715 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 979 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA/RNA helicase DHX36 between cysteines 715 and 716. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5vhe
Structure name
dhx36 in complex with the c-myc g-quadruplex
Structure deposition date
2017-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
82
Peptide accession
Q05B79
Residue number A
715
Residue number B
716
Peptide name
ATP-dependent DNA/RNA helicase DHX36

Ligandability

Cysteine 715 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 716 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA/RNA helicase DHX36 between cysteines 263 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5vhd
Structure name
dhx36 with an n-terminal truncation bound to adp-alf4
Structure deposition date
2017-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
Q05B79
Residue number A
263
Residue number B
312
Peptide name
ATP-dependent DNA/RNA helicase DHX36

Ligandability

Cysteine 263 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of ATP-dependent DNA/RNA helicase DHX36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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