ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Homeodomain-interacting protein kinase 2

Intramolecular
Cysteine 266 and cysteine 274
Cysteine 216 and cysteine 274
A redox-regulated disulphide may form within Homeodomain-interacting protein kinase 2 between cysteines 266 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6p5s
Structure name
hipk2 kinase domain bound to cx-4945
Structure deposition date
2019-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
28
Peptide accession
Q9H2X6
Residue number A
266
Residue number B
274
Peptide name
Homeodomain-interacting protein kinase 2

Ligandability

Cysteine 266 of Homeodomain-interacting protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Homeodomain-interacting protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Homeodomain-interacting protein kinase 2 between cysteines 216 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7ncf
Structure name
crystal structure of hipk2 in complex with mu135 (compound 21e)
Structure deposition date
2021-01-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
84
Peptide accession
Q9H2X6
Residue number A
216
Residue number B
274
Peptide name
Homeodomain-interacting protein kinase 2

Ligandability

Cysteine 216 of Homeodomain-interacting protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Homeodomain-interacting protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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