ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Intermolecular
Cysteine 106 and cysteine 106
Cysteine 106 and cysteine 107
Cysteine 107 and cysteine 107
Intramolecular
Cysteine 81 and cysteine 87
A redox-regulated disulphide may form between two units of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase at cysteines 106 and 106.

Details

Redox score ?
71
PDB code
6bw6
Structure name
human gpt (dpagt1) h129 variant in complex with tunicamycin
Structure deposition date
2017-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
93
Minimum pKa ?
5
% buried
100
Peptide A name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide B name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide A accession
Q9H3H5
Peptide B accession
Q9H3H5
Peptide A residue number
106
Peptide B residue number
106

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase at cysteines 106 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6bw5
Structure name
human gpt (dpagt1) in complex with tunicamycin
Structure deposition date
2017-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
98
Minimum pKa ?
13
% buried
nan
Peptide A name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide B name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide A accession
Q9H3H5
Peptide B accession
Q9H3H5
Peptide A residue number
106
Peptide B residue number
107

Ligandability

Cysteine 106 of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase at cysteines 107 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
6bw5
Structure name
human gpt (dpagt1) in complex with tunicamycin
Structure deposition date
2017-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
13
% buried
100
Peptide A name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide B name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Peptide A accession
Q9H3H5
Peptide B accession
Q9H3H5
Peptide A residue number
107
Peptide B residue number
107

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase between cysteines 81 and 87.

Details

Redox score ?
70
PDB code
6bw6
Structure name
human gpt (dpagt1) h129 variant in complex with tunicamycin
Structure deposition date
2017-12-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
Q9H3H5
Residue number A
81
Residue number B
87
Peptide name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Ligandability

Cysteine 81 of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: