a tool for identifying drug-targetable redox-active disulphides

Mitochondrial translation release factor in rescue

Intramolecular

Cysteine 84 and cysteine 98

A redox-regulated disulphide may form within Mitochondrial translation release factor in rescue between cysteines 84 and 98 (69 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

54

PDB code

Structure name

solution structure and sirna-mediated knockdown analysis of the mitochondrial disease-related protein c12orf65 (ict2)

Structure deposition date

2012-03-28

Thiol separation (Å)

8

Half-sphere exposure sum ?

61

Minimum pK_a ?

9

% buried

6

Peptide accession

Residue number A

84

Residue number B

98

Peptide name

Mitochondrial translation release factor in rescue

Ligandability

Cysteine 84 of Mitochondrial translation release factor in rescue

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Mitochondrial translation release factor in rescue

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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