ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ataxin-3-like protein

Intramolecular
Cysteine 14 and cysteine 18
Cysteine 18 and cysteine 114
A redox-regulated disulphide may form within Ataxin-3-like protein between cysteines 14 and 18 (15 and 19 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3o65
Structure name
crystal structure of a josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity
Structure deposition date
2010-07-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
90
Peptide accession
Q9H3M9
Residue number A
14
Residue number B
18
Peptide name
Ataxin-3-like protein

Ligandability

Cysteine 14 of Ataxin-3-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 18 of Ataxin-3-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ataxin-3-like protein between cysteines 18 and 114 (19 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3o65
Structure name
crystal structure of a josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity
Structure deposition date
2010-07-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H3M9
Residue number A
18
Residue number B
114
Peptide name
Ataxin-3-like protein

Ligandability

Cysteine 18 of Ataxin-3-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Ataxin-3-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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