ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysine-specific demethylase 4C

Intramolecular
Cysteine 236 and cysteine 310
Cysteine 308 and cysteine 310
Cysteine 236 and cysteine 308
A redox-regulated disulphide may form within Lysine-specific demethylase 4C between cysteines 236 and 310.

Details

Redox score ?
89
PDB code
5kr7
Structure name
kdm4c bound to pyrazolo-pyrimidine scaffold
Structure deposition date
2016-07-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
8
Peptide accession
Q9H3R0
Residue number A
236
Residue number B
310
Peptide name
Lysine-specific demethylase 4C

Ligandability

Cysteine 236 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4C between cysteines 308 and 310.

Details

Redox score ?
87
PDB code
5kr7
Structure name
kdm4c bound to pyrazolo-pyrimidine scaffold
Structure deposition date
2016-07-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
1
Peptide accession
Q9H3R0
Residue number A
308
Residue number B
310
Peptide name
Lysine-specific demethylase 4C

Ligandability

Cysteine 308 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4C between cysteines 236 and 308.

Details

Redox score ?
85
PDB code
4xdp
Structure name
crystal structure of human kdm4c catalytic domain bound to tris
Structure deposition date
2014-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
12
Peptide accession
Q9H3R0
Residue number A
236
Residue number B
308
Peptide name
Lysine-specific demethylase 4C

Ligandability

Cysteine 236 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Lysine-specific demethylase 4C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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