ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinetochore-associated protein DSN1 homolog

Intermolecular
Cysteine 191 and cysteine 40 of Kinetochore-associated protein NSL1 homolog
Cysteine 191 and cysteine 53 of Kinetochore-associated protein NSL1 homolog
A redox-regulated disulphide may form between cysteine 191 of Kinetochore-associated protein DSN1 homolog and cysteine 40 of Kinetochore-associated protein NSL1 homolog. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5lsi
Structure name
crystal structure of the kinetochore mis12 complex head2 subdomain containing dsn1 and nsl1 fragments
Structure deposition date
2016-09-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
78
Peptide A name
Kinetochore-associated protein DSN1 homolog
Peptide B name
Kinetochore-associated protein NSL1 homolog
Peptide A accession
Q9H410
Peptide B accession
Q96IY1
Peptide A residue number
191
Peptide B residue number
40

Ligandability

Cysteine 191 of Kinetochore-associated protein DSN1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Kinetochore-associated protein NSL1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 191 of Kinetochore-associated protein DSN1 homolog and cysteine 53 of Kinetochore-associated protein NSL1 homolog. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5lsi
Structure name
crystal structure of the kinetochore mis12 complex head2 subdomain containing dsn1 and nsl1 fragments
Structure deposition date
2016-09-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
79
Peptide A name
Kinetochore-associated protein DSN1 homolog
Peptide B name
Kinetochore-associated protein NSL1 homolog
Peptide A accession
Q9H410
Peptide B accession
Q96IY1
Peptide A residue number
191
Peptide B residue number
53

Ligandability

Cysteine 191 of Kinetochore-associated protein DSN1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of Kinetochore-associated protein NSL1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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