Frizzled-8
Intermolecular
Cysteine 107 and cysteine 148
Cysteine 107 and cysteine 107
Intramolecular
Cysteine 35 and cysteine 96
Cysteine 111 and cysteine 135
Cysteine 43 and cysteine 89
Cysteine 80 and cysteine 118
Cysteine 107 and cysteine 111
1ijy A 80 B 121
A redox-regulated disulphide may form between two units of Frizzled-8 at cysteines 107 and 148 (80 and 121 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
1ijy
Structure name
crystal structure of the cysteine-rich domain of mouse frizzled 8 (mfz8)
Structure deposition date
2001-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Frizzled-8
Peptide B name
Frizzled-8
Peptide A accession
Q61091
Peptide B accession
Q61091
Peptide A residue number
107
Peptide B residue number
148
Ligandability
Cysteine 107 of Frizzled-8
Cysteine 148 of Frizzled-8
1ijy A 80 B 80
A redox-regulated disulphide may form between two units of Frizzled-8 at cysteines 107 and 107 (80 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
1ijy
Structure name
crystal structure of the cysteine-rich domain of mouse frizzled 8 (mfz8)
Structure deposition date
2001-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Frizzled-8
Peptide B name
Frizzled-8
Peptide A accession
Q61091
Peptide B accession
Q61091
Peptide A residue number
107
Peptide B residue number
107
Ligandability
6tfm A 35 A 96
A redox-regulated disulphide may form within Frizzled-8 between cysteines 35 and 96.
Details
Redox score ?
85
PDB code
6tfm
Structure name
frizzled8 crd
Structure deposition date
2019-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q61091
Residue number A
35
Residue number B
96
Peptide name
Frizzled-8
Ligandability
Cysteine 35 of Frizzled-8
Cysteine 96 of Frizzled-8
5un5 B 84 B 108
A redox-regulated disulphide may form within Frizzled-8 between cysteines 111 and 135 (84 and 108 respectively in this structure).
Details
Redox score ?
85
PDB code
5un5
Structure name
frizzled-8 complex with designed surrogate wnt agonist, crystal form 1
Structure deposition date
2017-01-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H461
Residue number A
111
Residue number B
135
Peptide name
Frizzled-8
Ligandability
Cysteine 111 of Frizzled-8
Cysteine 135 of Frizzled-8
1ijy B 16 B 62
A redox-regulated disulphide may form within Frizzled-8 between cysteines 43 and 89 (16 and 62 respectively in this structure).
Details
Redox score ?
84
PDB code
1ijy
Structure name
crystal structure of the cysteine-rich domain of mouse frizzled 8 (mfz8)
Structure deposition date
2001-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q61091
Residue number A
43
Residue number B
89
Peptide name
Frizzled-8
Ligandability
Cysteine 43 of Frizzled-8
Cysteine 89 of Frizzled-8
6ndz A 53 A 91
A redox-regulated disulphide may form within Frizzled-8 between cysteines 80 and 118 (53 and 91 respectively in this structure).
Details
Redox score ?
83
PDB code
6ndz
Structure name
designed repeat protein in complex with fz8
Structure deposition date
2018-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H461
Residue number A
80
Residue number B
118
Peptide name
Frizzled-8
Ligandability
Cysteine 80 of Frizzled-8
Cysteine 118 of Frizzled-8
6ahy E 107 E 111
A redox-regulated disulphide may form within Frizzled-8 between cysteines 107 and 111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6ahy
Structure name
wnt signaling complex
Structure deposition date
2018-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
nan
Peptide accession
Q61091
Residue number A
107
Residue number B
111
Peptide name
Frizzled-8
Ligandability
Cysteine 107 of Frizzled-8
Cysteine 111 of Frizzled-8
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