ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribokinase

Intramolecular
Cysteine 24 and cysteine 73
Cysteine 198 and cysteine 229
Cysteine 59 and cysteine 73
Cysteine 197 and cysteine 198
Cysteine 197 and cysteine 241
Cysteine 24 and cysteine 59
A redox-regulated disulphide may form within Ribokinase between cysteines 24 and 73.

Details

Redox score ?
68
PDB code
5c40
Structure name
crystal structure of human ribokinase in complex with amppcp in p21 spacegroup
Structure deposition date
2015-06-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
107
Minimum pKa ?
8
% buried
100
Peptide accession
Q9H477
Residue number A
24
Residue number B
73
Peptide name
Ribokinase

Ligandability

Cysteine 24 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribokinase between cysteines 198 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2fv7
Structure name
crystal structure of human ribokinase
Structure deposition date
2006-01-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H477
Residue number A
198
Residue number B
229
Peptide name
Ribokinase

Ligandability

Cysteine 198 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribokinase between cysteines 59 and 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5c3y
Structure name
structure of human ribokinase crystallized with amppnp
Structure deposition date
2015-06-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
107
Minimum pKa ?
8
% buried
100
Peptide accession
Q9H477
Residue number A
59
Residue number B
73
Peptide name
Ribokinase

Ligandability

Cysteine 59 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribokinase between cysteines 197 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5bye
Structure name
crystal structure of human ribokinase in p212121 spacegroup
Structure deposition date
2015-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q9H477
Residue number A
197
Residue number B
198
Peptide name
Ribokinase

Ligandability

Cysteine 197 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribokinase between cysteines 197 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5byf
Structure name
crystal structure of human ribokinase in complex with amp
Structure deposition date
2015-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
98
Peptide accession
Q9H477
Residue number A
197
Residue number B
241
Peptide name
Ribokinase

Ligandability

Cysteine 197 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribokinase between cysteines 24 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
5byf
Structure name
crystal structure of human ribokinase in complex with amp
Structure deposition date
2015-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
108
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H477
Residue number A
24
Residue number B
59
Peptide name
Ribokinase

Ligandability

Cysteine 24 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Ribokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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