ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDP-fucose protein O-fucosyltransferase 1

Intramolecular
Cysteine 131 and cysteine 145
Cysteine 254 and cysteine 288
Cysteine 38 and cysteine 40
Cysteine 267 and cysteine 354
Cysteine 288 and cysteine 359
Cysteine 249 and cysteine 354
Cysteine 267 and cysteine 283
A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 131 and 145.

Details

Redox score ?
83
PDB code
5ky8
Structure name
mouse pofut1 in complex with o-glucosylated mouse notch1 egf12 mutant (d464g) and gdp
Structure deposition date
2016-07-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91ZW2
Residue number A
131
Residue number B
145
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 131 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 254 and 288.

Details

Redox score ?
82
PDB code
5ky8
Structure name
mouse pofut1 in complex with o-glucosylated mouse notch1 egf12 mutant (d464g) and gdp
Structure deposition date
2016-07-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91ZW2
Residue number A
254
Residue number B
288
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 254 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 38 and 40.

Details

Redox score ?
78
PDB code
5ux6
Structure name
structure of human pofut1 in its apo form
Structure deposition date
2017-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H488
Residue number A
38
Residue number B
40
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 38 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 267 and 354.

Details

Redox score ?
77
PDB code
5ux6
Structure name
structure of human pofut1 in its apo form
Structure deposition date
2017-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H488
Residue number A
267
Residue number B
354
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 267 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 288 and 359. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5ky4
Structure name
mouse pofut1 in complex with mouse notch1 egf26 and gdp
Structure deposition date
2016-07-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91ZW2
Residue number A
288
Residue number B
359
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 288 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 359 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 249 and 354. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5ux6
Structure name
structure of human pofut1 in its apo form
Structure deposition date
2017-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H488
Residue number A
249
Residue number B
354
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 249 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDP-fucose protein O-fucosyltransferase 1 between cysteines 267 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5ux6
Structure name
structure of human pofut1 in its apo form
Structure deposition date
2017-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H488
Residue number A
267
Residue number B
283
Peptide name
GDP-fucose protein O-fucosyltransferase 1

Ligandability

Cysteine 267 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of GDP-fucose protein O-fucosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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