a tool for identifying drug-targetable redox-active disulphides

Phosphatidylinositol glycan anchor biosynthesis class U protein

Intramolecular

Cysteine 154 and cysteine 160

A redox-regulated disulphide may form within Phosphatidylinositol glycan anchor biosynthesis class U protein between cysteines 154 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

29

PDB code

Structure name

cryo-em structure of the human glycosylphosphatidylinositol transamidase complex at 2

Structure deposition date

2022-01-13

Thiol separation (Å)

9

Half-sphere exposure sum ?

89

Minimum pK_a ?

11

% buried

92

Peptide accession

Residue number A

154

Residue number B

160

Peptide name

Phosphatidylinositol glycan anchor biosynthesis class U protein

Ligandability

Cysteine 154 of Phosphatidylinositol glycan anchor biosynthesis class U protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Phosphatidylinositol glycan anchor biosynthesis class U protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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