a tool for identifying drug-targetable redox-active disulphides

Microtubule-associated proteins 1A/1B light chain 3A

Intermolecular

Cysteine 17 and cysteine 17

A redox-regulated disulphide may form between two units of Microtubule-associated proteins 1A/1B light chain 3A at cysteines 17 and 17. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

crystal structure of fyco1 lir in complex with lc3a

Structure deposition date

2015-07-28

Thiol separation (Å)

9

Half-sphere exposure sum ?

66

Minimum pK_a ?

11

% buried

60

Peptide A name

Microtubule-associated proteins 1A/1B light chain 3A

Peptide B name

Microtubule-associated proteins 1A/1B light chain 3A

Peptide A accession

Peptide B accession

Peptide A residue number

17

Peptide B residue number

17

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: