ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Dipeptidase 3

Intramolecular
Cysteine 297 and cysteine 329
Cysteine 146 and cysteine 225
Cysteine 168 and cysteine 191
A redox-regulated disulphide may form within Dipeptidase 3 between cysteines 297 and 329.

Details

Redox score ?
85
PDB code
6vgo
Structure name
crystal structure of human dipeptidase 3
Structure deposition date
2020-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H4B8
Residue number A
297
Residue number B
329
Peptide name
Dipeptidase 3

Ligandability

Cysteine 297 of Dipeptidase 3

Cysteine 329 of Dipeptidase 3

A redox-regulated disulphide may form within Dipeptidase 3 between cysteines 146 and 225.

Details

Redox score ?
81
PDB code
6vgr
Structure name
crystal structure of human dipeptidase 3 in complex with fab of sc-003
Structure deposition date
2020-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H4B8
Residue number A
146
Residue number B
225
Peptide name
Dipeptidase 3

Ligandability

Cysteine 146 of Dipeptidase 3

Cysteine 225 of Dipeptidase 3

A redox-regulated disulphide may form within Dipeptidase 3 between cysteines 168 and 191.

Details

Redox score ?
73
PDB code
6vgr
Structure name
crystal structure of human dipeptidase 3 in complex with fab of sc-003
Structure deposition date
2020-01-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
100
Peptide accession
Q9H4B8
Residue number A
168
Residue number B
191
Peptide name
Dipeptidase 3

Ligandability

Cysteine 168 of Dipeptidase 3

Cysteine 191 of Dipeptidase 3

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