ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Piezo-type mechanosensitive ion channel component 2

Intramolecular
Cysteine 1031 and cysteine 1209
Cysteine 1188 and cysteine 1192
Cysteine 695 and cysteine 805
Cysteine 1144 and cysteine 1252
Cysteine 270 and cysteine 272
Cysteine 1187 and cysteine 1188
Cysteine 1144 and cysteine 1187
Cysteine 2437 and cysteine 2781
Cysteine 1341 and cysteine 1435
A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1031 and 1209.

Details

Redox score ?
88
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CD54
Residue number A
1031
Residue number B
1209
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1031 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1209 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1188 and 1192.

Details

Redox score ?
70
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
10
Peptide accession
Q8CD54
Residue number A
1188
Residue number B
1192
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1188 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1192 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 695 and 805. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
90
Peptide accession
Q8CD54
Residue number A
695
Residue number B
805
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 695 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 805 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1144 and 1252. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
82
Peptide accession
Q8CD54
Residue number A
1144
Residue number B
1252
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1144 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1252 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 270 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
29
Peptide accession
Q8CD54
Residue number A
270
Residue number B
272
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 270 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1187 and 1188. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
46
Peptide accession
Q8CD54
Residue number A
1187
Residue number B
1188
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1187 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1188 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1144 and 1187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
90
Peptide accession
Q8CD54
Residue number A
1144
Residue number B
1187
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1144 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1187 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 2437 and 2781. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
98
Peptide accession
Q8CD54
Residue number A
2437
Residue number B
2781
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 2437 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2781 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 2 between cysteines 1341 and 1435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6kg7
Structure name
cryo-em structure of the mammalian tactile channel piezo2
Structure deposition date
2019-07-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
98
Peptide accession
Q8CD54
Residue number A
1341
Residue number B
1435
Peptide name
Piezo-type mechanosensitive ion channel component 2

Ligandability

Cysteine 1341 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1435 of Piezo-type mechanosensitive ion channel component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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