ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ribonuclease P protein subunit p21

Intramolecular
Cysteine 62 and cysteine 92
Cysteine 92 and cysteine 95
Cysteine 75 and cysteine 92
Cysteine 65 and cysteine 95
Cysteine 62 and cysteine 95
Cysteine 65 and cysteine 92
Cysteine 62 and cysteine 65
Cysteine 39 and cysteine 65
Cysteine 62 and cysteine 75
Cysteine 75 and cysteine 95
More...
Cysteine 65 and cysteine 75
Cysteine 39 and cysteine 62
A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 62 and 92.

Details

Redox score ?
86
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
4
% buried
62
Peptide accession
Q9H633
Residue number A
62
Residue number B
92
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 62 of Ribonuclease P protein subunit p21

Cysteine 92 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 92 and 95.

Details

Redox score ?
77
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9H633
Residue number A
92
Residue number B
95
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 92 of Ribonuclease P protein subunit p21

Cysteine 95 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 75 and 92.

Details

Redox score ?
74
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
4
% buried
54
Peptide accession
Q9H633
Residue number A
75
Residue number B
92
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 75 of Ribonuclease P protein subunit p21

Cysteine 92 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 65 and 95.

Details

Redox score ?
70
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
53
Peptide accession
Q9H633
Residue number A
65
Residue number B
95
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 65 of Ribonuclease P protein subunit p21

Cysteine 95 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 62 and 95.

Details

Redox score ?
61
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
56
Peptide accession
Q9H633
Residue number A
62
Residue number B
95
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 62 of Ribonuclease P protein subunit p21

Cysteine 95 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 65 and 92. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
nan
Peptide accession
Q9H633
Residue number A
65
Residue number B
92
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 65 of Ribonuclease P protein subunit p21

Cysteine 92 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 62 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
68
Peptide accession
Q9H633
Residue number A
62
Residue number B
65
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 62 of Ribonuclease P protein subunit p21

Cysteine 65 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 39 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
80
Peptide accession
Q9H633
Residue number A
39
Residue number B
65
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 39 of Ribonuclease P protein subunit p21

Cysteine 65 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 62 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
62
Peptide accession
Q9H633
Residue number A
62
Residue number B
75
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 62 of Ribonuclease P protein subunit p21

Cysteine 75 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 75 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
48
Peptide accession
Q9H633
Residue number A
75
Residue number B
95
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 75 of Ribonuclease P protein subunit p21

Cysteine 95 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 65 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
60
Peptide accession
Q9H633
Residue number A
65
Residue number B
75
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 65 of Ribonuclease P protein subunit p21

Cysteine 75 of Ribonuclease P protein subunit p21

A redox-regulated disulphide may form within Ribonuclease P protein subunit p21 between cysteines 39 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
86
Peptide accession
Q9H633
Residue number A
39
Residue number B
62
Peptide name
Ribonuclease P protein subunit p21

Ligandability

Cysteine 39 of Ribonuclease P protein subunit p21

Cysteine 62 of Ribonuclease P protein subunit p21

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