a tool for identifying drug-targetable redox-active disulphides

CST complex subunit STN1

Intramolecular

Cysteine 312 and cysteine 322

Cysteine 312 and cysteine 330

Cysteine 322 and cysteine 330

Cysteine 86 and cysteine 88

A redox-regulated disulphide may form within CST complex subunit STN1 between cysteines 312 and 322.

Details

Redox score ?

73

PDB code

Structure name

human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template

Structure deposition date

2022-05-26

Thiol separation (Å)

4

Half-sphere exposure sum ?

67

Minimum pK_a ?

10

% buried

46

Peptide accession

Residue number A

312

Residue number B

322

Peptide name

CST complex subunit STN1

Ligandability

Cysteine 312 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CST complex subunit STN1 between cysteines 312 and 330.

Details

Redox score ?

69

PDB code

Structure name

structure of the c-terminal domain of human telomeric stn1

Structure deposition date

2013-03-20

Thiol separation (Å)

4

Half-sphere exposure sum ?

62

Minimum pK_a ?

10

% buried

nan

Peptide accession

Residue number A

312

Residue number B

330

Peptide name

CST complex subunit STN1

Ligandability

Cysteine 312 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CST complex subunit STN1 between cysteines 322 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

structure of the c-terminal domain of human telomeric stn1

Structure deposition date

2013-03-20

Thiol separation (Å)

6

Half-sphere exposure sum ?

64

Minimum pK_a ?

10

% buried

nan

Peptide accession

Residue number A

322

Residue number B

330

Peptide name

CST complex subunit STN1

Ligandability

Cysteine 322 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CST complex subunit STN1 between cysteines 86 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

50

PDB code

Structure name

crystal structure of the human telomeric stn1-ten1 complex

Structure deposition date

2013-03-18

Thiol separation (Å)

6

Half-sphere exposure sum ?

81

Minimum pK_a ?

12

% buried

91

Peptide accession

Residue number A

86

Residue number B

88

Peptide name

CST complex subunit STN1

Ligandability

Cysteine 86 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of CST complex subunit STN1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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