ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

WD repeat-containing protein 55

Intramolecular
Cysteine 69 and cysteine 306
Cysteine 258 and cysteine 268 L
A redox-regulated disulphide may form within WD repeat-containing protein 55 between cysteines 69 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7kqq
Structure name
crystal structure of human wdr55
Structure deposition date
2020-11-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H6Y2
Residue number A
69
Residue number B
306
Peptide name
WD repeat-containing protein 55

Ligandability

Cysteine 69 of WD repeat-containing protein 55

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of WD repeat-containing protein 55

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 55 between cysteines 258 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7kqq
Structure name
crystal structure of human wdr55
Structure deposition date
2020-11-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H6Y2
Residue number A
258
Residue number B
268
Peptide name
WD repeat-containing protein 55

Ligandability

Cysteine 258 of WD repeat-containing protein 55

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 268 of WD repeat-containing protein 55

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: