Gremlin-2
Intermolecular
Cysteine 120 and cysteine 120
Cysteine 101 and cysteine 101
Cysteine 120 and cysteine 101
Cysteine 120 and cysteine 123
Intramolecular
Cysteine 87 and cysteine 137
Cysteine 73 and cysteine 123
Cysteine 97 and cysteine 155
Cysteine 101 and cysteine 157
Cysteine 73 and cysteine 155
Cysteine 73 and cysteine 157
More...Cysteine 123 and cysteine 155
Cysteine 73 and cysteine 101
Cysteine 97 and cysteine 123
Cysteine 123 and cysteine 157
Cysteine 73 and cysteine 97
Cysteine 101 and cysteine 123
Cysteine 155 and cysteine 157
Cysteine 101 and cysteine 155
Cysteine 97 and cysteine 157
Cysteine 97 and cysteine 101
5hk5 E 120 F 120
A redox-regulated disulphide may form between two units of Gremlin-2 at cysteines 120 and 120.
Details
Redox score ?
65
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
7
% buried
50
Peptide A name
Gremlin-2
Peptide B name
Gremlin-2
Peptide A accession
O88273
Peptide B accession
O88273
Peptide A residue number
120
Peptide B residue number
120
Ligandability
5hk5 G 101 H 101
A redox-regulated disulphide may form between two units of Gremlin-2 at cysteines 101 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gremlin-2
Peptide B name
Gremlin-2
Peptide A accession
O88273
Peptide B accession
O88273
Peptide A residue number
101
Peptide B residue number
101
Ligandability
4jph C 120 D 101
A redox-regulated disulphide may form between two units of Gremlin-2 at cysteines 120 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gremlin-2
Peptide B name
Gremlin-2
Peptide A accession
O88273
Peptide B accession
O88273
Peptide A residue number
120
Peptide B residue number
101
Ligandability
Cysteine 120 of Gremlin-2
Cysteine 101 of Gremlin-2
4jph C 120 D 123
A redox-regulated disulphide may form between two units of Gremlin-2 at cysteines 120 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gremlin-2
Peptide B name
Gremlin-2
Peptide A accession
O88273
Peptide B accession
O88273
Peptide A residue number
120
Peptide B residue number
123
Ligandability
Cysteine 120 of Gremlin-2
Cysteine 123 of Gremlin-2
4jph D 87 D 137
A redox-regulated disulphide may form within Gremlin-2 between cysteines 87 and 137.
Details
Redox score ?
90
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
87
Residue number B
137
Peptide name
Gremlin-2
Ligandability
Cysteine 87 of Gremlin-2
Cysteine 137 of Gremlin-2
4jph A 73 A 123
A redox-regulated disulphide may form within Gremlin-2 between cysteines 73 and 123.
Details
Redox score ?
85
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
73
Residue number B
123
Peptide name
Gremlin-2
Ligandability
Cysteine 73 of Gremlin-2
Cysteine 123 of Gremlin-2
4jph C 97 C 155
A redox-regulated disulphide may form within Gremlin-2 between cysteines 97 and 155.
Details
Redox score ?
83
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
97
Residue number B
155
Peptide name
Gremlin-2
Ligandability
Cysteine 97 of Gremlin-2
Cysteine 155 of Gremlin-2
4jph A 101 A 157
A redox-regulated disulphide may form within Gremlin-2 between cysteines 101 and 157.
Details
Redox score ?
82
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
101
Residue number B
157
Peptide name
Gremlin-2
Ligandability
Cysteine 101 of Gremlin-2
Cysteine 157 of Gremlin-2
5hk5 E 73 E 155
A redox-regulated disulphide may form within Gremlin-2 between cysteines 73 and 155.
Details
Redox score ?
71
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
73
Residue number B
155
Peptide name
Gremlin-2
Ligandability
Cysteine 73 of Gremlin-2
Cysteine 155 of Gremlin-2
5hk5 E 73 E 157
A redox-regulated disulphide may form within Gremlin-2 between cysteines 73 and 157.
Details
Redox score ?
70
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
73
Residue number B
157
Peptide name
Gremlin-2
Ligandability
Cysteine 73 of Gremlin-2
Cysteine 157 of Gremlin-2
5hk5 G 123 G 155
A redox-regulated disulphide may form within Gremlin-2 between cysteines 123 and 155.
Details
Redox score ?
68
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
123
Residue number B
155
Peptide name
Gremlin-2
Ligandability
Cysteine 123 of Gremlin-2
Cysteine 155 of Gremlin-2
4jph C 73 C 101
A redox-regulated disulphide may form within Gremlin-2 between cysteines 73 and 101.
Details
Redox score ?
66
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
73
Residue number B
101
Peptide name
Gremlin-2
Ligandability
Cysteine 73 of Gremlin-2
Cysteine 101 of Gremlin-2
5hk5 E 97 E 123
A redox-regulated disulphide may form within Gremlin-2 between cysteines 97 and 123.
Details
Redox score ?
65
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
97
Residue number B
123
Peptide name
Gremlin-2
Ligandability
Cysteine 97 of Gremlin-2
Cysteine 123 of Gremlin-2
4jph B 123 B 157
A redox-regulated disulphide may form within Gremlin-2 between cysteines 123 and 157.
Details
Redox score ?
63
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
123
Residue number B
157
Peptide name
Gremlin-2
Ligandability
Cysteine 123 of Gremlin-2
Cysteine 157 of Gremlin-2
4jph A 73 A 97
A redox-regulated disulphide may form within Gremlin-2 between cysteines 73 and 97.
Details
Redox score ?
63
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
73
Residue number B
97
Peptide name
Gremlin-2
Ligandability
Cysteine 73 of Gremlin-2
Cysteine 97 of Gremlin-2
4jph D 101 D 123
A redox-regulated disulphide may form within Gremlin-2 between cysteines 101 and 123.
Details
Redox score ?
63
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
101
Residue number B
123
Peptide name
Gremlin-2
Ligandability
Cysteine 101 of Gremlin-2
Cysteine 123 of Gremlin-2
4jph A 155 A 157
A redox-regulated disulphide may form within Gremlin-2 between cysteines 155 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
155
Residue number B
157
Peptide name
Gremlin-2
Ligandability
Cysteine 155 of Gremlin-2
Cysteine 157 of Gremlin-2
4jph A 101 A 155
A redox-regulated disulphide may form within Gremlin-2 between cysteines 101 and 155. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
101
Residue number B
155
Peptide name
Gremlin-2
Ligandability
Cysteine 101 of Gremlin-2
Cysteine 155 of Gremlin-2
4jph D 97 D 157
A redox-regulated disulphide may form within Gremlin-2 between cysteines 97 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4jph
Structure name
crystal structure of protein related to dan and cerberus (prdc)
Structure deposition date
2013-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
97
Residue number B
157
Peptide name
Gremlin-2
Ligandability
Cysteine 97 of Gremlin-2
Cysteine 157 of Gremlin-2
5hk5 F 97 F 101
A redox-regulated disulphide may form within Gremlin-2 between cysteines 97 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5hk5
Structure name
structure of the grem2-gdf5 inhibitory complex
Structure deposition date
2016-01-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88273
Residue number A
97
Residue number B
101
Peptide name
Gremlin-2
Ligandability
Cysteine 97 of Gremlin-2
Cysteine 101 of Gremlin-2
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