ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Methyltransferase-like protein 17, mitochondrial

Intramolecular
Cysteine 339 and cysteine 347
Cysteine 333 and cysteine 339
Cysteine 339 and cysteine 404
Cysteine 333 and cysteine 404
Cysteine 333 and cysteine 347
Cysteine 404 and cysteine 405
Cysteine 401 and cysteine 405
Cysteine 347 and cysteine 404
A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 339 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
8csu
Structure name
human mitochondrial small subunit assembly intermediate (state c*)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
88
Peptide accession
Q9H7H0
Residue number A
339
Residue number B
347
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 339 of Methyltransferase-like protein 17, mitochondrial

Cysteine 347 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 333 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
8csp
Structure name
human mitochondrial small subunit assembly intermediate (state a)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
91
Peptide accession
Q9H7H0
Residue number A
333
Residue number B
339
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 333 of Methyltransferase-like protein 17, mitochondrial

Cysteine 339 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 339 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
8csq
Structure name
human mitochondrial small subunit assembly intermediate (state b)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
86
Peptide accession
Q9H7H0
Residue number A
339
Residue number B
404
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 339 of Methyltransferase-like protein 17, mitochondrial

Cysteine 404 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 333 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
94
Peptide accession
Q9H7H0
Residue number A
333
Residue number B
404
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 333 of Methyltransferase-like protein 17, mitochondrial

Cysteine 404 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 333 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
100
Peptide accession
Q9H7H0
Residue number A
333
Residue number B
347
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 333 of Methyltransferase-like protein 17, mitochondrial

Cysteine 347 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 404 and 405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
74
Peptide accession
Q9H7H0
Residue number A
404
Residue number B
405
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 404 of Methyltransferase-like protein 17, mitochondrial

Cysteine 405 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 401 and 405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
80
Peptide accession
Q9H7H0
Residue number A
401
Residue number B
405
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 401 of Methyltransferase-like protein 17, mitochondrial

Cysteine 405 of Methyltransferase-like protein 17, mitochondrial

A redox-regulated disulphide may form within Methyltransferase-like protein 17, mitochondrial between cysteines 347 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8csr
Structure name
human mitochondrial small subunit assembly intermediate (state c)
Structure deposition date
2022-05-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
14
% buried
95
Peptide accession
Q9H7H0
Residue number A
347
Residue number B
404
Peptide name
Methyltransferase-like protein 17, mitochondrial

Ligandability

Cysteine 347 of Methyltransferase-like protein 17, mitochondrial

Cysteine 404 of Methyltransferase-like protein 17, mitochondrial

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