V-type immunoglobulin domain-containing suppressor of T-cell activation
Intramolecular
Cysteine 44 and cysteine 178
Cysteine 83 and cysteine 145
Cysteine 54 and cysteine 146
Cysteine 83 and cysteine 146
Cysteine 54 and cysteine 83
Cysteine 145 and cysteine 146
Cysteine 54 and cysteine 145
6mvl A 44 A 178
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 44 and 178.
Details
Redox score ?
87
PDB code
6mvl
Structure name
crystal structure of vista bound to a ph-selective antibody fab fragment
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
44
Residue number B
178
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 44 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 178 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6mvl A 83 A 145
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 83 and 145.
Details
Redox score ?
82
PDB code
6mvl
Structure name
crystal structure of vista bound to a ph-selective antibody fab fragment
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
83
Residue number B
145
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 83 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 145 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6u6v A 22 A 114
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 54 and 146 (22 and 114 respectively in this structure).
Details
Redox score ?
80
PDB code
6u6v
Structure name
crystal structure of human pd-1h / vista
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
54
Residue number B
146
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 54 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 146 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6u6v A 51 A 114
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 83 and 146 (51 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6u6v
Structure name
crystal structure of human pd-1h / vista
Structure deposition date
2019-08-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
83
Residue number B
146
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 83 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 146 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6oil A 22 A 51
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 54 and 83 (22 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6oil
Structure name
crystal structure of human vista extracellular domain
Structure deposition date
2019-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
54
Residue number B
83
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 54 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 83 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6mvl A 145 A 146
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 145 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6mvl
Structure name
crystal structure of vista bound to a ph-selective antibody fab fragment
Structure deposition date
2018-10-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
145
Residue number B
146
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 145 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 146 of V-type immunoglobulin domain-containing suppressor of T-cell activation
6oil A 22 A 113
A redox-regulated disulphide may form within V-type immunoglobulin domain-containing suppressor of T-cell activation between cysteines 54 and 145 (22 and 113 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6oil
Structure name
crystal structure of human vista extracellular domain
Structure deposition date
2019-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H7M9
Residue number A
54
Residue number B
145
Peptide name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Ligandability
Cysteine 54 of V-type immunoglobulin domain-containing suppressor of T-cell activation
Cysteine 145 of V-type immunoglobulin domain-containing suppressor of T-cell activation
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