ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Cation channel sperm-associated auxiliary subunit beta

Intramolecular
Cysteine 913 and cysteine 922
Cysteine 330 and cysteine 343
Cysteine 35 and cysteine 60
Cysteine 924 and cysteine 939
Cysteine 831 and cysteine 1039
Cysteine 189 and cysteine 302
Cysteine 922 and cysteine 924
Cysteine 913 and cysteine 924
Cysteine 922 and cysteine 939
Cysteine 913 and cysteine 939
A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 913 and 922.

Details

Redox score ?
87
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
24
Peptide accession
A2RTF1
Residue number A
913
Residue number B
922
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 913 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 922 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 330 and 343.

Details

Redox score ?
85
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2RTF1
Residue number A
330
Residue number B
343
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 330 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 35 and 60.

Details

Redox score ?
84
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2RTF1
Residue number A
35
Residue number B
60
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 35 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 924 and 939.

Details

Redox score ?
82
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2RTF1
Residue number A
924
Residue number B
939
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 924 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 831 and 1039.

Details

Redox score ?
82
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2RTF1
Residue number A
831
Residue number B
1039
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 831 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1039 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 189 and 302.

Details

Redox score ?
80
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2RTF1
Residue number A
189
Residue number B
302
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 189 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 922 and 924.

Details

Redox score ?
75
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
nan
Peptide accession
A2RTF1
Residue number A
922
Residue number B
924
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 922 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 924 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 913 and 924.

Details

Redox score ?
68
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
12
% buried
nan
Peptide accession
A2RTF1
Residue number A
913
Residue number B
924
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 913 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 924 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 922 and 939. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
nan
Peptide accession
A2RTF1
Residue number A
922
Residue number B
939
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 922 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit beta between cysteines 913 and 939. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
nan
Peptide accession
A2RTF1
Residue number A
913
Residue number B
939
Peptide name
Cation channel sperm-associated auxiliary subunit beta

Ligandability

Cysteine 913 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Cation channel sperm-associated auxiliary subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: