a tool for identifying drug-targetable redox-active disulphides

Prostaglandin E synthase 2

Intramolecular

Cysteine 110 and cysteine 113 L

A redox-regulated disulphide may form within Prostaglandin E synthase 2 between cysteines 110 and 113.

Details

Redox score ?

71

PDB code

Structure name

gsh-heme bound microsomal prostaglandin e synthase

Structure deposition date

2007-03-28

Thiol separation (Å)

3

Half-sphere exposure sum ?

78

Minimum pK_a ?

8

% buried

100

Peptide accession

Residue number A

110

Residue number B

113

Peptide name

Prostaglandin E synthase 2

Ligandability

Cysteine 110 of Prostaglandin E synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Prostaglandin E synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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