a tool for identifying drug-targetable redox-active disulphides

Proton-activated chloride channel

Intramolecular

Cysteine 128 and cysteine 149

A redox-regulated disulphide may form within Proton-activated chloride channel between cysteines 128 and 149.

Details

Redox score ?

84

PDB code

Structure name

structure of the human proton-activated chloride channel asor in resting conformation

Structure deposition date

2021-11-05

Thiol separation (Å)

4

Half-sphere exposure sum ?

58

Minimum pK_a ?

5

% buried

78

Peptide accession

Residue number A

128

Residue number B

149

Peptide name

Proton-activated chloride channel

Ligandability

Cysteine 128 of Proton-activated chloride channel

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Proton-activated chloride channel

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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