a tool for identifying drug-targetable redox-active disulphides

5' exonuclease Apollo

Intramolecular

Cysteine 149 and cysteine 303

A redox-regulated disulphide may form within 5' exonuclease Apollo between cysteines 149 and 303.

Details

Redox score ?

79

PDB code

Structure name

crystal structure of human 5' exonuclease apollo

Structure deposition date

2015-02-06

Thiol separation (Å)

5

Half-sphere exposure sum ?

58

Minimum pK_a ?

6

% buried

51

Peptide accession

Residue number A

149

Residue number B

303

Peptide name

5' exonuclease Apollo

Ligandability

Cysteine 149 of 5' exonuclease Apollo

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of 5' exonuclease Apollo

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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