ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin-conjugating enzyme E2 Z

Intramolecular
Cysteine 261 and cysteine 263
Cysteine 254 and cysteine 286
A redox-regulated disulphide may form within Ubiquitin-conjugating enzyme E2 Z between cysteines 261 and 263.

Details

Redox score ?
61
PDB code
5a4p
Structure name
structure of ube2z provides functional insight into specificity in the fat10 conjugation machinery
Structure deposition date
2015-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
58
Peptide accession
Q9H832
Residue number A
261
Residue number B
263
Peptide name
Ubiquitin-conjugating enzyme E2 Z

Ligandability

Cysteine 261 of Ubiquitin-conjugating enzyme E2 Z

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Ubiquitin-conjugating enzyme E2 Z

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin-conjugating enzyme E2 Z between cysteines 254 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5a4p
Structure name
structure of ube2z provides functional insight into specificity in the fat10 conjugation machinery
Structure deposition date
2015-06-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
84
Peptide accession
Q9H832
Residue number A
254
Residue number B
286
Peptide name
Ubiquitin-conjugating enzyme E2 Z

Ligandability

Cysteine 254 of Ubiquitin-conjugating enzyme E2 Z

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Ubiquitin-conjugating enzyme E2 Z

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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