a tool for identifying drug-targetable redox-active disulphides

Protein ECT2

Intramolecular

Cysteine 661 and cysteine 700

A redox-regulated disulphide may form within Protein ECT2 between cysteines 661 and 700 (630 and 669 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

37

PDB code

Structure name

crystal structure of the epithelial cell transforming 2 (ect2)

Structure deposition date

2019-10-07

Thiol separation (Å)

9

Half-sphere exposure sum ?

75

Minimum pK_a ?

12

% buried

83

Peptide accession

Residue number A

661

Residue number B

700

Peptide name

Protein ECT2

Ligandability

Cysteine 661 of Protein ECT2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 700 of Protein ECT2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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