ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Major seminal plasma glycoprotein PSP-II

Intramolecular
Cysteine 74 and cysteine 95
Cysteine 30 and cysteine 51
A redox-regulated disulphide may form within Major seminal plasma glycoprotein PSP-II between cysteines 74 and 95 (53 and 74 respectively in this structure).

Details

Redox score ?
87
PDB code
1spp
Structure name
the crystal structures of two members of the spermadhesin family reveal the folding of the cub domain
Structure deposition date
1997-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35496
Residue number A
74
Residue number B
95
Peptide name
Major seminal plasma glycoprotein PSP-II

Ligandability

Cysteine 74 of Major seminal plasma glycoprotein PSP-II

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Major seminal plasma glycoprotein PSP-II

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Major seminal plasma glycoprotein PSP-II between cysteines 30 and 51 (9 and 30 respectively in this structure).

Details

Redox score ?
85
PDB code
1spp
Structure name
the crystal structures of two members of the spermadhesin family reveal the folding of the cub domain
Structure deposition date
1997-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35496
Residue number A
30
Residue number B
51
Peptide name
Major seminal plasma glycoprotein PSP-II

Ligandability

Cysteine 30 of Major seminal plasma glycoprotein PSP-II

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Major seminal plasma glycoprotein PSP-II

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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