ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Queuine tRNA-ribosyltransferase accessory subunit 2

Intramolecular
Cysteine 351 and cysteine 356
Cysteine 351 and cysteine 353
Cysteine 353 and cysteine 356
Cysteine 143 and cysteine 174 L
Cysteine 353 and cysteine 355
Cysteine 355 and cysteine 356
Cysteine 103 and cysteine 151
Cysteine 351 and cysteine 355
Cysteine 33 and cysteine 392
A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 351 and 356.

Details

Redox score ?
92
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
2
% buried
73
Peptide accession
Q9H974
Residue number A
351
Residue number B
356
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 351 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 351 and 353.

Details

Redox score ?
92
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
2
% buried
80
Peptide accession
Q9H974
Residue number A
351
Residue number B
353
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 351 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 353 and 356.

Details

Redox score ?
75
PDB code
7ovs
Structure name
heterodimeric murine trna-guanine transglycosylase in the presence of anderson-evans type (tew) and strandberg type polyoxometalate (pom)
Structure deposition date
2021-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
B8ZXI1
Residue number A
353
Residue number B
356
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 353 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 143 and 174.

Details

Redox score ?
71
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
96
Peptide accession
Q9H974
Residue number A
143
Residue number B
174
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 143 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 353 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7ovo
Structure name
heterodimeric murine trna-guanine transglycosylase in complex with queuine
Structure deposition date
2021-06-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
93
Peptide accession
B8ZXI1
Residue number A
353
Residue number B
355
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 353 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 355 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7ovo
Structure name
heterodimeric murine trna-guanine transglycosylase in complex with queuine
Structure deposition date
2021-06-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
84
Peptide accession
B8ZXI1
Residue number A
355
Residue number B
356
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 355 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 103 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
30
Peptide accession
Q9H974
Residue number A
103
Residue number B
151
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 103 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 351 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7owz
Structure name
heterodimeric murine trna-guanine transglycosylase in complex with queuine and in the presence of anderson-evans type (tew) and strandberg type polyoxometalate (pom)
Structure deposition date
2021-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
B8ZXI1
Residue number A
351
Residue number B
355
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 351 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase accessory subunit 2 between cysteines 33 and 392. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7ovo
Structure name
heterodimeric murine trna-guanine transglycosylase in complex with queuine
Structure deposition date
2021-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
69
Peptide accession
B8ZXI1
Residue number A
33
Residue number B
392
Peptide name
Queuine tRNA-ribosyltransferase accessory subunit 2

Ligandability

Cysteine 33 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of Queuine tRNA-ribosyltransferase accessory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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