ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin-related protein 8

Intramolecular
Cysteine 293 and cysteine 522
Cysteine 280 and cysteine 293
Cysteine 521 and cysteine 522
Cysteine 332 and cysteine 340
Cysteine 280 and cysteine 522
Cysteine 280 and cysteine 292
Cysteine 293 and cysteine 521
Cysteine 317 and cysteine 351
Cysteine 292 and cysteine 293
Cysteine 292 and cysteine 522
A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 293 and 522.

Details

Redox score ?
62
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
14
% buried
74
Peptide accession
Q9H981
Residue number A
293
Residue number B
522
Peptide name
Actin-related protein 8

Ligandability

Cysteine 293 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 280 and 293.

Details

Redox score ?
60
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
100
Minimum pKa ?
10
% buried
98
Peptide accession
Q9H981
Residue number A
280
Residue number B
293
Peptide name
Actin-related protein 8

Ligandability

Cysteine 280 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 521 and 522. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
42
Peptide accession
Q9H981
Residue number A
521
Residue number B
522
Peptide name
Actin-related protein 8

Ligandability

Cysteine 521 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 332 and 340. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
13
% buried
86
Peptide accession
Q9H981
Residue number A
332
Residue number B
340
Peptide name
Actin-related protein 8

Ligandability

Cysteine 332 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 280 and 522. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
76
Peptide accession
Q9H981
Residue number A
280
Residue number B
522
Peptide name
Actin-related protein 8

Ligandability

Cysteine 280 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 280 and 292. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
104
Minimum pKa ?
10
% buried
100
Peptide accession
Q9H981
Residue number A
280
Residue number B
292
Peptide name
Actin-related protein 8

Ligandability

Cysteine 280 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 293 and 521. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
65
Peptide accession
Q9H981
Residue number A
293
Residue number B
521
Peptide name
Actin-related protein 8

Ligandability

Cysteine 293 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 521 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 317 and 351. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H981
Residue number A
317
Residue number B
351
Peptide name
Actin-related protein 8

Ligandability

Cysteine 317 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 292 and 293. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
102
Minimum pKa ?
14
% buried
98
Peptide accession
Q9H981
Residue number A
292
Residue number B
293
Peptide name
Actin-related protein 8

Ligandability

Cysteine 292 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 8 between cysteines 292 and 522. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4fo0
Structure name
human actin-related protein arp8 in its atp-bound state
Structure deposition date
2012-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
14
% buried
76
Peptide accession
Q9H981
Residue number A
292
Residue number B
522
Peptide name
Actin-related protein 8

Ligandability

Cysteine 292 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of Actin-related protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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