ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CCR4-NOT transcription complex subunit 10

Intermolecular
Cysteine 52 and cysteine 317 of CCR4-NOT transcription complex subunit 11
Intramolecular
Cysteine 290 and cysteine 293
Cysteine 361 and cysteine 377
Cysteine 399 and cysteine 464
Cysteine 293 and cysteine 327
Cysteine 290 and cysteine 327
Cysteine 398 and cysteine 399
Cysteine 46 and cysteine 52
Cysteine 377 and cysteine 398
Cysteine 293 and cysteine 361
Cysteine 398 and cysteine 464
A redox-regulated disulphide may form between cysteine 52 of CCR4-NOT transcription complex subunit 10 and cysteine 317 of CCR4-NOT transcription complex subunit 11.

Details

Redox score ?
69
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
26
Peptide A name
CCR4-NOT transcription complex subunit 10
Peptide B name
CCR4-NOT transcription complex subunit 11
Peptide A accession
Q9H9A5
Peptide B accession
Q9UKZ1
Peptide A residue number
52
Peptide B residue number
317

Ligandability

Cysteine 52 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 290 and 293.

Details

Redox score ?
62
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
74
Peptide accession
Q9H9A5
Residue number A
290
Residue number B
293
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 290 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 361 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
98
Peptide accession
Q9H9A5
Residue number A
361
Residue number B
377
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 361 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 399 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
98
Peptide accession
Q9H9A5
Residue number A
399
Residue number B
464
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 399 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 293 and 327. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
72
Peptide accession
Q9H9A5
Residue number A
293
Residue number B
327
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 293 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 327 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 290 and 327. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
56
Peptide accession
Q9H9A5
Residue number A
290
Residue number B
327
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 290 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 327 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 398 and 399. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
98
Peptide accession
Q9H9A5
Residue number A
398
Residue number B
399
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 398 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 399 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 46 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
34
Peptide accession
Q9H9A5
Residue number A
46
Residue number B
52
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 46 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 377 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
98
Peptide accession
Q9H9A5
Residue number A
377
Residue number B
398
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 377 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 293 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
94
Peptide accession
Q9H9A5
Residue number A
293
Residue number B
361
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 293 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 10 between cysteines 398 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
99
Minimum pKa ?
14
% buried
100
Peptide accession
Q9H9A5
Residue number A
398
Residue number B
464
Peptide name
CCR4-NOT transcription complex subunit 10

Ligandability

Cysteine 398 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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