ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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COP9 signalosome complex subunit 7b

Intermolecular
Cysteine 264 of COP9 signalosome complex subunit 6 and cysteine 181
Cysteine 264 of COP9 signalosome complex subunit 6 and cysteine 178
Cysteine 266 of COP9 signalosome complex subunit 6 and cysteine 157
Cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181
Intramolecular
Cysteine 178 and cysteine 181
A redox-regulated disulphide may form between cysteine 264 of COP9 signalosome complex subunit 6 and cysteine 181 of COP9 signalosome complex subunit 7b. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6r7i
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
51
Peptide A name
COP9 signalosome complex subunit 6
Peptide B name
COP9 signalosome complex subunit 7b
Peptide A accession
Q7L5N1
Peptide B accession
Q9H9Q2
Peptide A residue number
264
Peptide B residue number
181

Ligandability

Cysteine 264 of COP9 signalosome complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 264 of COP9 signalosome complex subunit 6 and cysteine 178 of COP9 signalosome complex subunit 7b. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6r6h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
96
Peptide A name
COP9 signalosome complex subunit 6
Peptide B name
COP9 signalosome complex subunit 7b
Peptide A accession
Q7L5N1
Peptide B accession
Q9H9Q2
Peptide A residue number
264
Peptide B residue number
178

Ligandability

Cysteine 264 of COP9 signalosome complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 266 of COP9 signalosome complex subunit 6 and cysteine 157 of COP9 signalosome complex subunit 7b. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6r7i
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
98
Peptide A name
COP9 signalosome complex subunit 6
Peptide B name
COP9 signalosome complex subunit 7b
Peptide A accession
Q7L5N1
Peptide B accession
Q9H9Q2
Peptide A residue number
266
Peptide B residue number
157

Ligandability

Cysteine 266 of COP9 signalosome complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181 of COP9 signalosome complex subunit 7b. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6r6h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide A name
COP9 signalosome complex subunit 4
Peptide B name
COP9 signalosome complex subunit 7b
Peptide A accession
Q9BT78
Peptide B accession
Q9H9Q2
Peptide A residue number
378
Peptide B residue number
181

Ligandability

Cysteine 378 of COP9 signalosome complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 7b between cysteines 178 and 181.

Details

Redox score ?
66
PDB code
6r6h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
96
Peptide accession
Q9H9Q2
Residue number A
178
Residue number B
181
Peptide name
COP9 signalosome complex subunit 7b

Ligandability

Cysteine 178 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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