ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Homeobox protein NANOG

Intermolecular
Cysteine 109 and cysteine 151
A redox-regulated disulphide may form between two units of Homeobox protein NANOG at cysteines 109 and 151 (14 and 56 respectively in this structure).

Details

Redox score ?
85
PDB code
2vi6
Structure name
crystal structure of the nanog homeodomain
Structure deposition date
2007-11-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Homeobox protein NANOG
Peptide B name
Homeobox protein NANOG
Peptide A accession
Q80Z64
Peptide B accession
Q80Z64
Peptide A residue number
109
Peptide B residue number
151

Ligandability

Cysteine 109 of Homeobox protein NANOG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Homeobox protein NANOG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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