ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ribitol 5-phosphate transferase FKRP

Intramolecular
Cysteine 168 and cysteine 191
Cysteine 289 and cysteine 317
Cysteine 289 and cysteine 296
Cysteine 296 and cysteine 318
Cysteine 296 and cysteine 317
Cysteine 289 and cysteine 318
Cysteine 317 and cysteine 318
A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 168 and 191.

Details

Redox score ?
83
PDB code
6kal
Structure name
crystal structure of fkrp in complex with mg ion and cmp
Structure deposition date
2019-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H9S5
Residue number A
168
Residue number B
191
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 168 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 289 and 317.

Details

Redox score ?
76
PDB code
6l7u
Structure name
crystal structure of fkrp in complex with ba ion, ba-sad data
Structure deposition date
2019-11-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H9S5
Residue number A
289
Residue number B
317
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 289 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 289 and 296.

Details

Redox score ?
74
PDB code
6kam
Structure name
crystal structure of fkrp in complex with ba ion, cdp-ribtol, and sugar acceptor
Structure deposition date
2019-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H9S5
Residue number A
289
Residue number B
296
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 289 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 296 and 318.

Details

Redox score ?
68
PDB code
6l7u
Structure name
crystal structure of fkrp in complex with ba ion, ba-sad data
Structure deposition date
2019-11-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H9S5
Residue number A
296
Residue number B
318
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 296 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 296 and 317.

Details

Redox score ?
68
PDB code
6l7t
Structure name
crystal structure of fkrp in complex with mg ion, zinc low remote data
Structure deposition date
2019-11-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9H9S5
Residue number A
296
Residue number B
317
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 296 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 289 and 318.

Details

Redox score ?
65
PDB code
6l7s
Structure name
crystal structure of fkrp in complex with mg ion, zinc peak data
Structure deposition date
2019-11-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
80
Peptide accession
Q9H9S5
Residue number A
289
Residue number B
318
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 289 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribitol 5-phosphate transferase FKRP between cysteines 317 and 318. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6l7t
Structure name
crystal structure of fkrp in complex with mg ion, zinc low remote data
Structure deposition date
2019-11-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
14
% buried
92
Peptide accession
Q9H9S5
Residue number A
317
Residue number B
318
Peptide name
Ribitol 5-phosphate transferase FKRP

Ligandability

Cysteine 317 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Ribitol 5-phosphate transferase FKRP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: