ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Elongator complex protein 3

Intramolecular
Cysteine 99 and cysteine 109
Cysteine 109 and cysteine 112
Cysteine 99 and cysteine 112
Cysteine 227 and cysteine 240 L
A redox-regulated disulphide may form within Elongator complex protein 3 between cysteines 99 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
93
Peptide accession
Q9CZX0
Residue number A
99
Residue number B
109
Peptide name
Elongator complex protein 3

Ligandability

Cysteine 99 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Elongator complex protein 3 between cysteines 109 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
98
Peptide accession
Q9CZX0
Residue number A
109
Residue number B
112
Peptide name
Elongator complex protein 3

Ligandability

Cysteine 109 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Elongator complex protein 3 between cysteines 99 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
94
Peptide accession
Q9CZX0
Residue number A
99
Residue number B
112
Peptide name
Elongator complex protein 3

Ligandability

Cysteine 99 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Elongator complex protein 3 between cysteines 227 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
98
Peptide accession
Q9CZX0
Residue number A
227
Residue number B
240
Peptide name
Elongator complex protein 3

Ligandability

Cysteine 227 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Elongator complex protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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