DNA-directed RNA polymerase I subunit RPA2
Intermolecular
Cysteine 535 and cysteine 85 of DNA-directed RNA polymerase I subunit RPA49
Cysteine 93 and cysteine 39 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1098
Cysteine 93 and cysteine 36 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
Cysteine 93 and cysteine 19 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
Cysteine 93 and cysteine 22 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
Cysteine 535 and cysteine 81 of DNA-directed RNA polymerase I subunit RPA49
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1070
Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 498
Cysteine 539 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1061 L
More...Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 689
Intramolecular
Cysteine 1070 and cysteine 1101
Cysteine 1070 and cysteine 1098
Cysteine 1098 and cysteine 1101
Cysteine 1073 and cysteine 1101
Cysteine 1073 and cysteine 1098
Cysteine 1070 and cysteine 1073
Cysteine 214 and cysteine 333
Cysteine 855 and cysteine 868
Cysteine 498 and cysteine 689
Cysteine 294 and cysteine 307
Cysteine 855 and cysteine 866
Cysteine 866 and cysteine 868
Cysteine 103 and cysteine 146
7ob9 B 535 M 85
A redox-regulated disulphide may form between cysteine 535 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 85 of DNA-directed RNA polymerase I subunit RPA49.
Details
Redox score ?
71
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
88
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerase I subunit RPA49
Peptide A accession
Q9H9Y6
Peptide B accession
Q9GZS1
Peptide A residue number
535
Peptide B residue number
85
Ligandability
Cysteine 535 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 85 of DNA-directed RNA polymerase I subunit RPA49
7oba B 93 L 39
A redox-regulated disulphide may form between cysteine 93 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 39 of DNA-directed RNA polymerases I, II, and III subunit RPABC4.
Details
Redox score ?
67
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
36
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Peptide A accession
Q9H9Y6
Peptide B accession
P53803
Peptide A residue number
93
Peptide B residue number
39
Ligandability
Cysteine 93 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 39 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
8a43 A 67 B 1098
A redox-regulated disulphide may form between cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2.
Details
Redox score ?
62
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
60
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
67
Peptide B residue number
1098
Ligandability
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
7ob9 B 93 L 36
A redox-regulated disulphide may form between cysteine 93 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 36 of DNA-directed RNA polymerases I, II, and III subunit RPABC4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
34
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Peptide A accession
Q9H9Y6
Peptide B accession
P53803
Peptide A residue number
93
Peptide B residue number
36
Ligandability
Cysteine 93 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 36 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
7oba B 93 L 19
A redox-regulated disulphide may form between cysteine 93 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 19 of DNA-directed RNA polymerases I, II, and III subunit RPABC4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
51
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Peptide A accession
Q9H9Y6
Peptide B accession
P53803
Peptide A residue number
93
Peptide B residue number
19
Ligandability
Cysteine 93 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 19 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
7obb B 93 L 22
A redox-regulated disulphide may form between cysteine 93 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 22 of DNA-directed RNA polymerases I, II, and III subunit RPABC4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
24
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Peptide A accession
Q9H9Y6
Peptide B accession
P53803
Peptide A residue number
93
Peptide B residue number
22
Ligandability
Cysteine 93 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 22 of DNA-directed RNA polymerases I, II, and III subunit RPABC4
8a43 B 535 N 81
A redox-regulated disulphide may form between cysteine 535 of DNA-directed RNA polymerase I subunit RPA2 and cysteine 81 of DNA-directed RNA polymerase I subunit RPA49. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
85
Peptide A name
DNA-directed RNA polymerase I subunit RPA2
Peptide B name
DNA-directed RNA polymerase I subunit RPA49
Peptide A accession
Q9H9Y6
Peptide B accession
Q9GZS1
Peptide A residue number
535
Peptide B residue number
81
Ligandability
Cysteine 535 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 81 of DNA-directed RNA polymerase I subunit RPA49
8a43 A 67 B 1070
A redox-regulated disulphide may form between cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
59
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
67
Peptide B residue number
1070
Ligandability
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 968 B 498
A redox-regulated disulphide may form between cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 498 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
968
Peptide B residue number
498
Ligandability
Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 498 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 539 B 1061
A redox-regulated disulphide may form between cysteine 539 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1061 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
539
Peptide B residue number
1061
Ligandability
Cysteine 539 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1061 of DNA-directed RNA polymerase I subunit RPA2
7ob9 A 968 B 689
A redox-regulated disulphide may form between cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 689 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
968
Peptide B residue number
689
Ligandability
Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 689 of DNA-directed RNA polymerase I subunit RPA2
7obb B 1070 B 1101
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1070 and 1101.
Details
Redox score ?
84
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
14
Peptide accession
Q9H9Y6
Residue number A
1070
Residue number B
1101
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1101 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 1070 B 1098
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1070 and 1098.
Details
Redox score ?
80
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
56
Peptide accession
Q9H9Y6
Residue number A
1070
Residue number B
1098
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
7oba B 1098 B 1101
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1098 and 1101.
Details
Redox score ?
80
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
24
Peptide accession
Q9H9Y6
Residue number A
1098
Residue number B
1101
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1101 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 1073 B 1101
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1073 and 1101.
Details
Redox score ?
77
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
5
% buried
36
Peptide accession
Q9H9Y6
Residue number A
1073
Residue number B
1101
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1073 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1101 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 1073 B 1098
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1073 and 1098.
Details
Redox score ?
70
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
54
Peptide accession
Q9H9Y6
Residue number A
1073
Residue number B
1098
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1073 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
7obb B 1070 B 1073
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 1070 and 1073.
Details
Redox score ?
70
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
21
Peptide accession
Q9H9Y6
Residue number A
1070
Residue number B
1073
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 1073 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 214 B 333
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 214 and 333. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
92
Peptide accession
Q9H9Y6
Residue number A
214
Residue number B
333
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 214 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 333 of DNA-directed RNA polymerase I subunit RPA2
7ob9 B 855 B 868
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 855 and 868. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
100
Peptide accession
Q9H9Y6
Residue number A
855
Residue number B
868
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 855 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 868 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 498 B 689
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 498 and 689. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
100
Peptide accession
Q9H9Y6
Residue number A
498
Residue number B
689
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 498 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 689 of DNA-directed RNA polymerase I subunit RPA2
7oba B 294 B 307
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 294 and 307. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
40
Peptide accession
Q9H9Y6
Residue number A
294
Residue number B
307
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 294 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 307 of DNA-directed RNA polymerase I subunit RPA2
7oba B 855 B 866
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 855 and 866. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
88
Peptide accession
Q9H9Y6
Residue number A
855
Residue number B
866
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 855 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 866 of DNA-directed RNA polymerase I subunit RPA2
8a43 B 866 B 868
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 866 and 868. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9H9Y6
Residue number A
866
Residue number B
868
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 866 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 868 of DNA-directed RNA polymerase I subunit RPA2
7ob9 B 103 B 146
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA2 between cysteines 103 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
100
Peptide accession
Q9H9Y6
Residue number A
103
Residue number B
146
Peptide name
DNA-directed RNA polymerase I subunit RPA2
Ligandability
Cysteine 103 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 146 of DNA-directed RNA polymerase I subunit RPA2
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