Protein lin-28 homolog A
Intramolecular
Cysteine 161 and cysteine 174
Cysteine 139 and cysteine 152
Cysteine 142 and cysteine 152
Cysteine 161 and cysteine 164
Cysteine 164 and cysteine 174
Cysteine 139 and cysteine 142
Cysteine 44 and cysteine 117
3trz F 161 F 174
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 161 and 174.
Details
Redox score ?
91
PDB code
3trz
Structure name
mouse lin28a in complex with let-7d microrna pre-element
Structure deposition date
2011-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
4
% buried
48
Peptide accession
Q8K3Y3
Residue number A
161
Residue number B
174
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 161 of Protein lin-28 homolog A
Cysteine 174 of Protein lin-28 homolog A
3ts2 B 139 B 152
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 139 and 152.
Details
Redox score ?
88
PDB code
3ts2
Structure name
mouse lin28a in complex with let-7g microrna pre-element
Structure deposition date
2011-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
28
Peptide accession
Q8K3Y3
Residue number A
139
Residue number B
152
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 139 of Protein lin-28 homolog A
Cysteine 152 of Protein lin-28 homolog A
5udz A 142 A 152
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 142 and 152.
Details
Redox score ?
83
PDB code
5udz
Structure name
human lin28a in complex with let-7f-1 microrna pre-element
Structure deposition date
2016-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
30
Peptide accession
Q9H9Z2
Residue number A
142
Residue number B
152
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 142 of Protein lin-28 homolog A
Cysteine 152 of Protein lin-28 homolog A
5udz B 161 B 164
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 161 and 164.
Details
Redox score ?
82
PDB code
5udz
Structure name
human lin28a in complex with let-7f-1 microrna pre-element
Structure deposition date
2016-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
3
% buried
68
Peptide accession
Q9H9Z2
Residue number A
161
Residue number B
164
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 161 of Protein lin-28 homolog A
Cysteine 164 of Protein lin-28 homolog A
5udz B 164 B 174
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 164 and 174.
Details
Redox score ?
74
PDB code
5udz
Structure name
human lin28a in complex with let-7f-1 microrna pre-element
Structure deposition date
2016-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
53
Peptide accession
Q9H9Z2
Residue number A
164
Residue number B
174
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 164 of Protein lin-28 homolog A
Cysteine 174 of Protein lin-28 homolog A
5udz B 139 B 142
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 139 and 142.
Details
Redox score ?
71
PDB code
5udz
Structure name
human lin28a in complex with let-7f-1 microrna pre-element
Structure deposition date
2016-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
46
Peptide accession
Q9H9Z2
Residue number A
139
Residue number B
142
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 139 of Protein lin-28 homolog A
Cysteine 142 of Protein lin-28 homolog A
5udz B 44 B 117
A redox-regulated disulphide may form within Protein lin-28 homolog A between cysteines 44 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
5udz
Structure name
human lin28a in complex with let-7f-1 microrna pre-element
Structure deposition date
2016-12-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
Q9H9Z2
Residue number A
44
Residue number B
117
Peptide name
Protein lin-28 homolog A
Ligandability
Cysteine 44 of Protein lin-28 homolog A
Cysteine 117 of Protein lin-28 homolog A
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