Calcium homeostasis modulator protein 2
Intermolecular
Cysteine 204 and cysteine 86
Cysteine 179 and cysteine 46
Cysteine 179 and cysteine 130
Cysteine 179 and cysteine 48
Intramolecular
Cysteine 46 and cysteine 130
Cysteine 46 and cysteine 162
Cysteine 46 and cysteine 48
Cysteine 130 and cysteine 162
Cysteine 48 and cysteine 162
Cysteine 48 and cysteine 130
More...Cysteine 204 and cysteine 209
Cysteine 46 and cysteine 129
Cysteine 46 and cysteine 123
Cysteine 94 and cysteine 209
Cysteine 123 and cysteine 126
6uiw G 204 H 86
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 2 at cysteines 204 and 86. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6uiw
Structure name
cryo-em structure of human calhm2 in a ruthenium red-bound inhibited state
Structure deposition date
2019-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Calcium homeostasis modulator protein 2
Peptide B name
Calcium homeostasis modulator protein 2
Peptide A accession
Q9HA72
Peptide B accession
Q9HA72
Peptide A residue number
204
Peptide B residue number
86
Ligandability
Cysteine 204 of Calcium homeostasis modulator protein 2
Cysteine 86 of Calcium homeostasis modulator protein 2
6lmx F 179 G 41
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 2 at cysteines 179 and 46 (179 and 41 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6lmx
Structure name
cryo-em structure of the calhm chimeric construct (9-mer)
Structure deposition date
2019-12-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
nan
Peptide A name
Calcium homeostasis modulator protein 2
Peptide B name
Calcium homeostasis modulator protein 2
Peptide A accession
Q9HA72
Peptide B accession
Q9HA72
Peptide A residue number
179
Peptide B residue number
46
Ligandability
Cysteine 179 of Calcium homeostasis modulator protein 2
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 179 in protein A could not be asigned to a Uniprot residue.
6lmx F 179 G 126
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 2 at cysteines 179 and 130 (179 and 126 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6lmx
Structure name
cryo-em structure of the calhm chimeric construct (9-mer)
Structure deposition date
2019-12-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
nan
Peptide A name
Calcium homeostasis modulator protein 2
Peptide B name
Calcium homeostasis modulator protein 2
Peptide A accession
Q9HA72
Peptide B accession
Q9HA72
Peptide A residue number
179
Peptide B residue number
130
Ligandability
Cysteine 179 of Calcium homeostasis modulator protein 2
Cysteine 130 of Calcium homeostasis modulator protein 2
Cysteine 179 in protein A could not be asigned to a Uniprot residue.
6lmw G 179 H 43
A redox-regulated disulphide may form between two units of Calcium homeostasis modulator protein 2 at cysteines 179 and 48 (179 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6lmw
Structure name
cryo-em structure of the calhm chimeric construct (8-mer)
Structure deposition date
2019-12-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
nan
Peptide A name
Calcium homeostasis modulator protein 2
Peptide B name
Calcium homeostasis modulator protein 2
Peptide A accession
Q9HA72
Peptide B accession
Q9HA72
Peptide A residue number
179
Peptide B residue number
48
Ligandability
Cysteine 179 of Calcium homeostasis modulator protein 2
Cysteine 48 of Calcium homeostasis modulator protein 2
Cysteine 179 in protein A could not be asigned to a Uniprot residue.
6vai B 46 B 130
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 46 and 130.
Details
Redox score ?
80
PDB code
6vai
Structure name
cryo-em structure of a dimer of undecameric human calhm2
Structure deposition date
2019-12-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HA72
Residue number A
46
Residue number B
130
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 130 of Calcium homeostasis modulator protein 2
6val F 41 F 159
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 46 and 162 (41 and 159 respectively in this structure).
Details
Redox score ?
66
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9HA72
Residue number A
46
Residue number B
162
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 162 of Calcium homeostasis modulator protein 2
6uiw J 46 J 48
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 46 and 48.
Details
Redox score ?
64
PDB code
6uiw
Structure name
cryo-em structure of human calhm2 in a ruthenium red-bound inhibited state
Structure deposition date
2019-10-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HA72
Residue number A
46
Residue number B
48
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 48 of Calcium homeostasis modulator protein 2
6uiv C 130 C 162
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 130 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6uiv
Structure name
cryo-em structure of human calhm2 in an active/open state
Structure deposition date
2019-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HA72
Residue number A
130
Residue number B
162
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 130 of Calcium homeostasis modulator protein 2
Cysteine 162 of Calcium homeostasis modulator protein 2
6val B 43 B 159
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 48 and 162 (43 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
59
Peptide accession
Q9HA72
Residue number A
48
Residue number B
162
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 48 of Calcium homeostasis modulator protein 2
Cysteine 162 of Calcium homeostasis modulator protein 2
6vai G 48 G 130
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 48 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6vai
Structure name
cryo-em structure of a dimer of undecameric human calhm2
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HA72
Residue number A
48
Residue number B
130
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 48 of Calcium homeostasis modulator protein 2
Cysteine 130 of Calcium homeostasis modulator protein 2
6vai I 204 I 209
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 204 and 209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6vai
Structure name
cryo-em structure of a dimer of undecameric human calhm2
Structure deposition date
2019-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
7
Peptide accession
Q9HA72
Residue number A
204
Residue number B
209
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 204 of Calcium homeostasis modulator protein 2
Cysteine 209 of Calcium homeostasis modulator protein 2
6val H 41 H 129
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 46 and 129 (41 and 129 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9HA72
Residue number A
46
Residue number B
129
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 129 of Calcium homeostasis modulator protein 2
Cysteine 129 in protein B could not be asigned to a Uniprot residue.
6val G 41 G 123
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 46 and 123 (41 and 123 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9HA72
Residue number A
46
Residue number B
123
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 46 of Calcium homeostasis modulator protein 2
Cysteine 123 of Calcium homeostasis modulator protein 2
Cysteine 123 in protein B could not be asigned to a Uniprot residue.
6val D 100 D 207
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 94 and 209 (100 and 207 respectively in this structure).
Details
Redox score ?
nan
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
11
Peptide accession
Q9HA72
Residue number A
94
Residue number B
209
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 94 of Calcium homeostasis modulator protein 2
Cysteine 209 of Calcium homeostasis modulator protein 2
Uncertain whether structure cysteine 100 has been assigned to correct residue.
6val A 123 A 126
A redox-regulated disulphide may form within Calcium homeostasis modulator protein 2 between cysteines 123 and 126.
Details
Redox score ?
nan
PDB code
6val
Structure name
cryo-em structure of an undecameric chicken calhm1 and human calhm2 chimera
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9HA72
Residue number A
123
Residue number B
126
Peptide name
Calcium homeostasis modulator protein 2
Ligandability
Cysteine 123 of Calcium homeostasis modulator protein 2
Cysteine 126 of Calcium homeostasis modulator protein 2
Cysteine 123 in protein A could not be asigned to a Uniprot residue.
Cysteine 126 in protein B could not be asigned to a Uniprot residue.
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