WD repeat-containing protein 41

Intramolecular

A redox-regulated disulphide may form within WD repeat-containing protein 41 between cysteines 131 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6v4u

Structure name

cryo-em structure of smcr8-c9orf72-wdr41 complex

Structure deposition date

2019-12-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q9HAD4

Residue number A

131

Residue number B

156

Peptide name

WD repeat-containing protein 41

Ligandability

Cysteine 131 of WD repeat-containing protein 41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 156 of WD repeat-containing protein 41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 41 between cysteines 156 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6whh

Structure name

crystal structure of human wdr41

Structure deposition date

2020-04-08

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q9HAD4

Residue number A

156

Residue number B

166

Peptide name

WD repeat-containing protein 41

Ligandability

Cysteine 156 of WD repeat-containing protein 41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of WD repeat-containing protein 41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 41 between cysteines 340 and 422. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?