ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Regulator of nonsense transcripts 2

Intramolecular
Cysteine 592 and cysteine 632
Cysteine 811 and cysteine 812
Cysteine 710 and cysteine 755
Cysteine 687 and cysteine 710
Cysteine 704 and cysteine 755
Cysteine 221 and cysteine 226
Cysteine 312 and cysteine 315
A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 592 and 632.

Details

Redox score ?
77
PDB code
4cek
Structure name
crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
28
Peptide accession
Q9HAU5
Residue number A
592
Residue number B
632
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 592 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 632 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 811 and 812. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1uw4
Structure name
the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3
Structure deposition date
2004-01-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9HAU5
Residue number A
811
Residue number B
812
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 811 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 812 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 710 and 755. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4cek
Structure name
crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
88
Peptide accession
Q9HAU5
Residue number A
710
Residue number B
755
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 710 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 755 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 687 and 710. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4cek
Structure name
crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
93
Peptide accession
Q9HAU5
Residue number A
687
Residue number B
710
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 687 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 710 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 704 and 755. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4cek
Structure name
crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
82
Peptide accession
Q9HAU5
Residue number A
704
Residue number B
755
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 704 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 755 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 221 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4cem
Structure name
crystal structure of the first mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
73
Peptide accession
Q9HAU5
Residue number A
221
Residue number B
226
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 221 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 2 between cysteines 312 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4cem
Structure name
crystal structure of the first mif4g domain of human nonsense mediated decay factor upf2
Structure deposition date
2013-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
Q9HAU5
Residue number A
312
Residue number B
315
Peptide name
Regulator of nonsense transcripts 2

Ligandability

Cysteine 312 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Regulator of nonsense transcripts 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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