Exportin-5
Intramolecular
Cysteine 1044 and cysteine 1089 L
Cysteine 44 and cysteine 47 L
Cysteine 10 and cysteine 50 L
Cysteine 323 and cysteine 327
Cysteine 44 and cysteine 50 L
Cysteine 976 and cysteine 977 L
Cysteine 47 and cysteine 50 L
Cysteine 10 and cysteine 44 L
Cysteine 903 and cysteine 1017
Cysteine 646 and cysteine 724 L
More...Cysteine 736 and cysteine 765
Cysteine 605 and cysteine 646 L
3a6p F 1044 F 1089
A redox-regulated disulphide may form within Exportin-5 between cysteines 1044 and 1089.
Details
Redox score ?
85
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HAV4
Residue number A
1044
Residue number B
1089
Peptide name
Exportin-5
Ligandability
Cysteine 1044 of Exportin-5
Cysteine 1089 of Exportin-5
3a6p A 44 A 47
A redox-regulated disulphide may form within Exportin-5 between cysteines 44 and 47.
Details
Redox score ?
73
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
49
Peptide accession
Q9HAV4
Residue number A
44
Residue number B
47
Peptide name
Exportin-5
Ligandability
Cysteine 44 of Exportin-5
Cysteine 47 of Exportin-5
3a6p A 10 A 50
A redox-regulated disulphide may form within Exportin-5 between cysteines 10 and 50.
Details
Redox score ?
70
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
40
Peptide accession
Q9HAV4
Residue number A
10
Residue number B
50
Peptide name
Exportin-5
Ligandability
Cysteine 10 of Exportin-5
Cysteine 50 of Exportin-5
3a6p A 323 A 327
A redox-regulated disulphide may form within Exportin-5 between cysteines 323 and 327.
Details
Redox score ?
67
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
100
Peptide accession
Q9HAV4
Residue number A
323
Residue number B
327
Peptide name
Exportin-5
Ligandability
Cysteine 323 of Exportin-5
Cysteine 327 of Exportin-5
3a6p F 44 F 50
A redox-regulated disulphide may form within Exportin-5 between cysteines 44 and 50.
Details
Redox score ?
64
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
38
Peptide accession
Q9HAV4
Residue number A
44
Residue number B
50
Peptide name
Exportin-5
Ligandability
Cysteine 44 of Exportin-5
Cysteine 50 of Exportin-5
3a6p F 976 F 977
A redox-regulated disulphide may form within Exportin-5 between cysteines 976 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
95
Peptide accession
Q9HAV4
Residue number A
976
Residue number B
977
Peptide name
Exportin-5
Ligandability
Cysteine 976 of Exportin-5
Cysteine 977 of Exportin-5
3a6p A 47 A 50
A redox-regulated disulphide may form within Exportin-5 between cysteines 47 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
56
Peptide accession
Q9HAV4
Residue number A
47
Residue number B
50
Peptide name
Exportin-5
Ligandability
Cysteine 47 of Exportin-5
Cysteine 50 of Exportin-5
3a6p A 10 A 44
A redox-regulated disulphide may form within Exportin-5 between cysteines 10 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
33
Peptide accession
Q9HAV4
Residue number A
10
Residue number B
44
Peptide name
Exportin-5
Ligandability
Cysteine 10 of Exportin-5
Cysteine 44 of Exportin-5
3a6p A 903 A 1017
A redox-regulated disulphide may form within Exportin-5 between cysteines 903 and 1017. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
40
Peptide accession
Q9HAV4
Residue number A
903
Residue number B
1017
Peptide name
Exportin-5
Ligandability
Cysteine 903 of Exportin-5
Cysteine 1017 of Exportin-5
3a6p A 646 A 724
A redox-regulated disulphide may form within Exportin-5 between cysteines 646 and 724. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
96
Peptide accession
Q9HAV4
Residue number A
646
Residue number B
724
Peptide name
Exportin-5
Ligandability
Cysteine 646 of Exportin-5
Cysteine 724 of Exportin-5
3a6p A 736 A 765
A redox-regulated disulphide may form within Exportin-5 between cysteines 736 and 765. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
86
Peptide accession
Q9HAV4
Residue number A
736
Residue number B
765
Peptide name
Exportin-5
Ligandability
Cysteine 736 of Exportin-5
Cysteine 765 of Exportin-5
3a6p A 605 A 646
A redox-regulated disulphide may form within Exportin-5 between cysteines 605 and 646. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
3a6p
Structure name
crystal structure of exportin-5:rangtp:pre-mirna complex
Structure deposition date
2009-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
100
Peptide accession
Q9HAV4
Residue number A
605
Residue number B
646
Peptide name
Exportin-5
Ligandability
Cysteine 605 of Exportin-5
Cysteine 646 of Exportin-5
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