ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription factor IIIB 50 kDa subunit

Intermolecular
Cysteine 370 and cysteine 262 of TATA-box-binding protein
Intramolecular
Cysteine 80 and cysteine 126
Cysteine 245 and cysteine 251
Cysteine 120 and cysteine 121
Cysteine 120 and cysteine 139
Cysteine 80 and cysteine 121
A redox-regulated disulphide may form between cysteine 370 of Transcription factor IIIB 50 kDa subunit and cysteine 262 of TATA-box-binding protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5n9g
Structure name
tfiiib -tbp/brf2/dna and sant domain of bdp1-
Structure deposition date
2017-02-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
58
Peptide A name
Transcription factor IIIB 50 kDa subunit
Peptide B name
TATA-box-binding protein
Peptide A accession
Q9HAW0
Peptide B accession
P20226
Peptide A residue number
370
Peptide B residue number
262

Ligandability

Cysteine 370 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of TATA-box-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor IIIB 50 kDa subunit between cysteines 80 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4roe
Structure name
human tfiib-related factor 2 (brf2) and tbp bound to rpph1 promoter
Structure deposition date
2014-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
60
Peptide accession
Q9HAW0
Residue number A
80
Residue number B
126
Peptide name
Transcription factor IIIB 50 kDa subunit

Ligandability

Cysteine 80 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor IIIB 50 kDa subunit between cysteines 245 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4roc
Structure name
human tfiib-related factor 2 (brf2) and tbp bound to u6#2 promoter
Structure deposition date
2014-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
56
Peptide accession
Q9HAW0
Residue number A
245
Residue number B
251
Peptide name
Transcription factor IIIB 50 kDa subunit

Ligandability

Cysteine 245 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor IIIB 50 kDa subunit between cysteines 120 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4roe
Structure name
human tfiib-related factor 2 (brf2) and tbp bound to rpph1 promoter
Structure deposition date
2014-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q9HAW0
Residue number A
120
Residue number B
121
Peptide name
Transcription factor IIIB 50 kDa subunit

Ligandability

Cysteine 120 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor IIIB 50 kDa subunit between cysteines 120 and 139. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5n9g
Structure name
tfiiib -tbp/brf2/dna and sant domain of bdp1-
Structure deposition date
2017-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
88
Peptide accession
Q9HAW0
Residue number A
120
Residue number B
139
Peptide name
Transcription factor IIIB 50 kDa subunit

Ligandability

Cysteine 120 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor IIIB 50 kDa subunit between cysteines 80 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5n9g
Structure name
tfiiib -tbp/brf2/dna and sant domain of bdp1-
Structure deposition date
2017-02-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
80
Peptide accession
Q9HAW0
Residue number A
80
Residue number B
121
Peptide name
Transcription factor IIIB 50 kDa subunit

Ligandability

Cysteine 80 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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