ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity protein kinase CLK4

Intramolecular
Cysteine 149 and cysteine 236
Cysteine 176 and cysteine 236
A redox-regulated disulphide may form within Dual specificity protein kinase CLK4 between cysteines 149 and 236 (151 and 238 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6fyv
Structure name
x-ray structure of clk4-kd(146-480)/cx-4945 at 2
Structure deposition date
2018-03-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
44
Peptide accession
Q9HAZ1
Residue number A
149
Residue number B
236
Peptide name
Dual specificity protein kinase CLK4

Ligandability

Cysteine 149 of Dual specificity protein kinase CLK4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Dual specificity protein kinase CLK4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual specificity protein kinase CLK4 between cysteines 176 and 236 (178 and 238 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6fyv
Structure name
x-ray structure of clk4-kd(146-480)/cx-4945 at 2
Structure deposition date
2018-03-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
70
Peptide accession
Q9HAZ1
Residue number A
176
Residue number B
236
Peptide name
Dual specificity protein kinase CLK4

Ligandability

Cysteine 176 of Dual specificity protein kinase CLK4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Dual specificity protein kinase CLK4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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