ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-1 receptor-like 2

Intramolecular
Cysteine 22 and cysteine 103
Cysteine 146 and cysteine 195
Cysteine 118 and cysteine 165
Cysteine 42 and cysteine 95
Cysteine 22 and cysteine 95
A redox-regulated disulphide may form within Interleukin-1 receptor-like 2 between cysteines 22 and 103.

Details

Redox score ?
87
PDB code
6u6u
Structure name
il36r extracellular domain in complex with bi655130 fab
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB29
Residue number A
22
Residue number B
103
Peptide name
Interleukin-1 receptor-like 2

Ligandability

Cysteine 22 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 2 between cysteines 146 and 195.

Details

Redox score ?
83
PDB code
6u6u
Structure name
il36r extracellular domain in complex with bi655130 fab
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB29
Residue number A
146
Residue number B
195
Peptide name
Interleukin-1 receptor-like 2

Ligandability

Cysteine 146 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 2 between cysteines 118 and 165.

Details

Redox score ?
82
PDB code
6u6u
Structure name
il36r extracellular domain in complex with bi655130 fab
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB29
Residue number A
118
Residue number B
165
Peptide name
Interleukin-1 receptor-like 2

Ligandability

Cysteine 118 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 2 between cysteines 42 and 95.

Details

Redox score ?
81
PDB code
6u6u
Structure name
il36r extracellular domain in complex with bi655130 fab
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB29
Residue number A
42
Residue number B
95
Peptide name
Interleukin-1 receptor-like 2

Ligandability

Cysteine 42 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 2 between cysteines 22 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6u6u
Structure name
il36r extracellular domain in complex with bi655130 fab
Structure deposition date
2019-08-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HB29
Residue number A
22
Residue number B
95
Peptide name
Interleukin-1 receptor-like 2

Ligandability

Cysteine 22 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Interleukin-1 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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