a tool for identifying drug-targetable redox-active disulphides

GHRH receptor splice variant 1

Intramolecular

Cysteine 138 and cysteine 208

A redox-regulated disulphide may form within GHRH receptor splice variant 1 between cysteines 138 and 208.

Details

Redox score ?

86

PDB code

Structure name

cryo-em structure of the sv1-gs complex

Structure deposition date

2021-08-26

Thiol separation (Å)

2

Half-sphere exposure sum ?

62

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

138

Residue number B

208

Peptide name

GHRH receptor splice variant 1

Ligandability

Cysteine 138 of GHRH receptor splice variant 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of GHRH receptor splice variant 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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