ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related GTP-binding protein C

Intramolecular
Cysteine 285 and cysteine 286
Cysteine 284 and cysteine 338
A redox-regulated disulphide may form within Ras-related GTP-binding protein C between cysteines 285 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6s6a
Structure name
crystal structure of raga-q66l/ragc-t90n gtpase heterodimer complex
Structure deposition date
2019-07-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide accession
Q9HB90
Residue number A
285
Residue number B
286
Peptide name
Ras-related GTP-binding protein C

Ligandability

Cysteine 285 of Ras-related GTP-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Ras-related GTP-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-related GTP-binding protein C between cysteines 284 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5x6v
Structure name
crystal structure of human heteroheptameric complex
Structure deposition date
2017-02-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q99K70
Residue number A
284
Residue number B
338
Peptide name
Ras-related GTP-binding protein C

Ligandability

Cysteine 284 of Ras-related GTP-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Ras-related GTP-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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